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Sun Apr 12

• Modeling the interactions between osteoblast and osteoclast activities in bone remodeling ? CellML: In the paper described here, Lemaine et al. present a mathematical model of the interactions which occur between osteoblasts and osteoclasts in the process of bone remodelling. Using this model the authors were able to simulate skeletal disease by inserting dysfunctional connections in the coupling network to explore different disease hypotheses.
• ScienceDirect - Journal of Theoretical Biology : Modeling the interactions between osteoblast and osteoclast activities in bone remodeling: The model results corroborate all behaviors of the bone remodeling system that we have simulated, including the tight coupling between osteoblasts and osteoclasts, the catabolic effect induced by continuous administration of PTH, the catabolic action of RANKL, as well as its reversal by soluble antagonist OPG. The model is also able to simulate metabolic bone diseases such as estrogen deficiency, vitamin D deficiency, senescence and glucocorticoid excess. Conversely, possible routes for therapeutic interventions are tested and evaluated. Our model confirms that anti-resorptiv e therapies are unable to partially restore bone loss, whereas bone formation therapies yield better results.

Sat Apr 11

• [Regulation of receptor activator of nuclear facto...[Zhong hua Yi Xue Za Zhi. 2008] - PubMed Result: CONCLUSION: PGE2 can up-regulate the expression of RANKL but down-regulate the expression of OPG. The up-regulation of RANKL mRNA expression by PGE2 was mediated through the activation of PKA signaling pathway while PGE2 induced down-regulatio n of OPG mRNA expression was predominantly mediated via PKA as well as the Ca2+ /Calmodulin signaling pathways.

Fri Apr 10

• IL-17 in synovial fluids from patients with rheuma...[J Clin Invest. 1999] - PubMed Result: Osteoclastogen esis inhibitory factor (OCIF), a decoy receptor of ODF, completely inhibited IL-17-induced osteoclast differentiatio n in the cocultures. Levels of IL-17 in synovial fluids were significantly higher in rheumatoid arthritis (RA) patients than osteoarthritis (OA) patients. Anti-IL-17 antibody significantly inhibited osteoclast formation induced by culture media of RA synovial tissues. These findings suggest that IL-17 first acts on osteoblasts, which stimulates both COX-2-dependen t PGE2 synthesis and ODF gene expression, which in turn induce differentiatio n of osteoclast progenitors into mature osteoclasts, and that IL-17 is a crucial cytokine for osteoclastic bone resorption in RA patients.
• Differential modulation of RANKL isoforms by human...[Bone. 2008] - PubMed Result: CONCLUSION: Our findings showed that the normal, L- and H-OA subchondral bone osteoblasts differentially express membranous RANKL and RANKL isoforms, and that treatment with osteotropic factors generally favours increased membranous localization of RANKL on L-OA compared to H-OA osteoblasts. This phenomenon appears to take place through differential modulation of each RANKL isoform.
• Differential modulation of RANKL isoforms by human...[Bone. 2008] - PubMed Result: CONCLUSION: Our findings showed that the normal, L- and H-OA subchondral bone osteoblasts differentially express membranous RANKL and RANKL isoforms, and that treatment with osteotropic factors generally favours increased membranous localization of RANKL on L-OA compared to H-OA osteoblasts. This phenomenon appears to take place through differential modulation of each RANKL isoform.
• The differential expression of osteoprotegeri n (OP...[Clin Exp Rheumatol. 2008 Mar-Apr] - PubMed Result

Sat Mar 28

• Osteoprotegeri n administration reduces femural bon...[J Electron Microsc (Tokyo). 2002] - PubMed Result: Ultrastructura lly, OPG administration caused disappearance of ruffled borders in most osteoclasts, but induced neither necrotic nor apoptotic changes. In addition, the expression of vacuolar-type H+-ATPase in osteoclasts was decreased by OPG administration . Our results suggest that low-dose OPG administration significantly reduces trabecular bone loss in OVX mice via impairment of the structure and bone resorbing activity of osteoclasts.
• Effects of chemically modified tetracycline, CMT-8...[Ann N Y Acad Sci. 1999] - PubMed Result: Our results suggest that CMT-8 therapy effectively inhibits post-ovariecto my bone loss not only by inducing new bone formation, but also by inhibiting osteoclastic bone resorption, and that CMT-8 binding to bone may provide a prolonged release delivery of this anti-resorptiv e therapy.
• Effects of chemically modified tetracycline, CMT-8...[Ann N Y Acad Sci. 1999] - PubMed Result: Our results suggest that CMT-8 therapy effectively inhibits post-ovariecto my bone loss not only by inducing new bone formation, but also by inhibiting osteoclastic bone resorption, and that CMT-8 binding to bone may provide a prolonged release delivery of this anti-resorptiv e therapy.

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